Disintegration plays an important role for tablets and capsules to break into small fragments to release the drug.Many students and professionals are not familiar with disintegration time of different types of tablets & capsules.In current article you will learn,
- What is disintegration?
- Apparatus Used For Disintegration test?
- Disintegration time for different tablets and capsules?
What is disintegration?
The breakdown of tablets and capsules into small fragments which can pass through mesh number 10 is known as disintegration and a test used to check the disintegration time is known as disintegration test.
Apparatus for Disintegration?
The apparatus used for disintegration testing is known as basket rack assembly or disintegration tester.
Disintegration Time?
One of the most important interview and viva questions related to disintegration is the disintegration time of different tablets and capsules.As per BP disintegration times are given as below.
What is disintegration time of uncoated tablets?
The uncoated or core tablets should disintegrate in not more than 15 minutes.
What is disintegration time of film coated tablets?
Film coated tablets should disintegrate in NMT (not more than) 30 minutes.
What is disintegration time of sugar coated tablets?
Sugar coated tablets should disintegrate in NMT (not more than) 60 minutes.
What is disintegration time of enteric coated tablets?
The enteric coated tablets should remain stable for 2 hours in acidic media and should disintegrate within 1 hour in basic media.
What is disintegration time of effervescent tablets?
All effervescent tablets should disintegrate within 5 minutes.
What is disintegration time of dispersible tablets?
Not more than 3 minutes is the disintegration time limit for dispersible tablets.
What is disintegration time for orodispersible tablets?
Fast dissolving tablets or orodispersible ODT tablets should disintegrate in time not more than 30 seconds.
What is disintegration time for chewable tablets?
For chewable tablets this test is not performed.
Disintegration time of empty hard gelatin capsules is?
Empty hard gelatin capsules shells should disintegrate in not more than 15 minutes.
What is the disintegration time of filled hard gelatin capsules?
Filled hard gelatin capsules should disintegrate in not more than 30 minutes.
Disintegration time of soft gelatin capsules Is?
Soft gelatin capsules should disintegrate in not more than 60 minutes.