Sunday, October 17, 2021

Blank Dies For Compression Machine | Tablet Compression

Dies are the hollow structures and important tools used for compression of tablets, lozenges and pills by using the compression machines in the pharmaceutical industries.

Role Of Dies

  • The weight of the product being compressed depends on the dies.

  • The powders or granules are filled in the die bore, then the weight is adjusted according to the formulation and is  compressed by upper and lower punches.

  • Lower punch remains inside the die bore from the lower side of the die to prevent product loss from the die bore.

Read details

Stages and Mechanism of Tablet Compression.

Sunday, October 3, 2021

Enteric Coating | Enteric Coated Tablets | Enteric Coated Pellets

Enteric coating is a process in which a layer of polymer is applied to the oral solid dosage forms to protect the drug release in the acidic environment of the stomach and to release the drug in alkaline pH in the small intestine.

Meant By Enteric Coating?

One commonly asked question is what is the meaning of enteric coating? so the answer is as follows,

  • The word enteric is related to the intestine and its meaning is within the intestine or affecting the intestine so enteric coating is any type of coating which ensures drug release in the intestine.

From above mentioned answer we can easily understand the answer of one more common question which is 

Where do enteric coated tablets dissolve?

As we discussed earlier the enteric coated medicines are dissolved in the small intestine at basic pH.

Sunday, September 26, 2021

Kollidon CL | Crospovidone | Kollidon CL Used

Crospovidone is a cross-linked polyvinylpyrrolidone or Crosslinked PVP and is used as a super disintegrant in manufacturing of oral solid dosage forms in pharmaceutical industries.

Other Names

The other names used for crospovidone are as follow,

  • Kollidon CL

  • Kollidon CL M

  • PVPP

  • Crosspovidonum

  • Cross Linked Povidone

  • Polyplasdone XL

  • Insoluble Polyvinylpyrollidone  

Mechanism Of Crospovidone

  • Crospovidone is insoluble in water and gives its disintegration effect by swelling without forming gel.