Q:1
What Is RMG?
RMG is an abbreviation of rapid mixing granulator. It is used in the pharma industry for manufacturing tablets by the wet granulation process.
Q:2
Another name for RMG?
Another name of RMG is High shear mixing granulator.
Q:3
Purpose of RMG?
Rapid mixing granulator serves the following functions,
- Mixing of dry powders
- Kneading process
- Breakdown of wet mass
Q:4
Principle of RMG?
The working principle of RMV is very simple; it works on the principle of shear.
Q:5
MOC of RMG?
The material of construction for the rapid mixing granulator is stainless steel grade 316L.
Q:6
Alternative to RMG?
RMG is an example of high shear mixing granulators, and its alternatives are low shear mixing granulators like
- Sigma mixer
- Plough Mixer
Q:7
Manufacturers of RMG?
The well-known RMG manufacturers are
- Cannon
Q:8
Components of RMG?
A rapid mixing granulator consists of the following main parts,
- Mixing Bowl
- Lid
- Pneumatic Seals
- Binder Hopper
- Vent Filter
- Impeller Blades
- Chopper
- Wet Mill
- HMI
Q:9
What is a pneumatic Lid?
Pneumatic lid is a tightly closed lid opened & closed by compressed air.It is used to seal the mixing bowl of a rapid mixing granulator.
Q:10
What Is Air Purging in RMG?
A continuous stream of compressed air comes out through the impeller and chopper blades and is known as air purging.
Q:11
Benefits of air purging?
Air purging is the safety feature of the rapid mixing granulator & it remains ON during washing and processing as well.
Due to air purging, the product is not accumulated below the seals of the impeller and copper during processing & air purging prevents water entry into motor shafts during washing.
Q:12
Role of the vent filter?
Another name for the Vent filter is
The breathing filter & its function are to release the pressure from the mixing bowl.
Q:13
Types of vent filters?
Two types of vent filters are used
- SS vent filter
- Cloth vent filter
Q:14
Function of RMG impeller blades?
The impeller blades of the rapid mixing granulator are used for uniform mixing of powders.
The impeller blades uniformly spread the binder during the kneading process and ensure uniform binder distribution.
Q:15
Function of the RMG chopper?
Copper breaks down large lumps formed during the wetting process.
The breakdown of large lumps prevents localized overwetting.
Q:16
Number of motors in RMG?
Two motors are installed in the rapid mixing granulator. One main motor is used to rotate the impeller blades.
Another motor is used for choppers to rotate the blades of the chopper.
Q:17
Mechanism of binder addition?
The binder addition mechanism may depend on the make and model of the rapid mixing granulator, as in some old models we can add binder solution manually through the hopper and in advanced types of RMGs, the auto transferring through a peristaltic pump or by pressurised vessel is done.
Q:18
CPPs of RMG?
Rapid mixing granulator CPPs or critical process parameters are,
- Impeller speed
- Chopper Speed
- Kneading Time
- Binder addition Rate
- Wet Mill Speed
Q:19
End point determination in RMG?
The following methods are used
- Kneading time
- Binder addition rate
- Power consumption method
- Banana technique
- Near Infrared Method
- Acoustic Emission Method
Q:20
Safety features of RMG?
Safety features of RMG are,
- Lid sealing sensor
- Impeller overload sensor
- Chopper overload sensor
- Wet mill overload sensor
- Wet mill alignment sensor
- Interlocking system
- Air purging system
Q:21
Sensors installed in RMG?
Same as mentioned in the safety features of RMG.
Q:22
Function of the overload sensor?
Overload sensor senses the load on the impeller, chopper & wet mill & turns off the RMG if the load exceeds the recommended value.
Q:23
What is interlocking in RMG?
Interlocking in RMG is a safety feature which ensures that a rapid mixing granulator will only work if both the doors of the mixing bowl and wet mill are locked.
Q:24
What is the Wet Mill of RMG?
Wet mill is attached below the discharging port of a rapid mixing granulator and it breaks the wet mass into small granules to facilitate the drying process.
Q:25
Product charging to RMG?
In the latest models, the product is changed through a pneumatic transferring system, but in old models, the product is transferred to the mixing bowl by a manual process.
Q:26
Product discharging from RMG?
In advanced models, the product is discharged directly to the fluid bed dryer through pneumatic suction & in old models, the product is collected directly into containers of FBD product trolleys.
Q:27
Cleaning of RMG?
CIP or clean-in-place system is provided with advanced types of rapid mixing granulators, where the rapid mixing granulator is washed without dismantling.
Q:28
Capacity of RMG?
The capacity of a rapid mixing granulator is always mentioned in litres instead of kilograms, and it may vary depending on the model.
Q:29
Benefits of RMG?
- GMP compliant
- Ensures fast processing.
- 21 CFR compliance.
- Easy to wash with CIP.
Q:30
Drawbacks of RMG?
- It is costly equipment
- Have a large footprint.
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