Monday, October 12, 2020

Pharmaceutical Questions and answer for interview


What is Production?

All the activities involved in the manufacturing of a pharmaceutical product starting from receipt of raw materials to the completion of a finished product means, from Raw material Receipt to Finished product dispatch.

It contains the handling of manpower and recording of the manufacturing and the packing activity.

What is Batch Manufacturing Record(BMR)

BMR is a Document that provides a history of a batch mean how a product is manufactured step by step following written procedures.

It contains signs of qualified persons and operators involved in manufacturing.

What is Batch packaging Record (BPR)

Batch packaging record or  BPR is the document that provides a history of batch packaging and in-process checks of Packaging.

Define Tablet

Tablet is a solid dosage form prepared by a combination of API and Excipients by application of pressure.

What is API

API stands for Active pharmaceutical ingredient.

API is a substance that gives pharmacological effects.

What is Excipient

Inert materials which do not give any pharmacological effect.

Classification of Excipients for Solid Dosage form

  • Diluents
  • Binders
  • Disintegrants
  • Glidents
  • Lubricants
  • Colourants
  • Flavours

Tests for Tablet

  • Weight variation
  • Thickness
  • Hardness
  • Friability
  • Disintegration
  • Dissolution
  • Assay
  • Content uniformity

what are Defects of Tablet

  • Capping
  • Lamination
  • Sticking
  • Picking
  • Weight Variation

What is Disintegration

The time needed for tablet or capsule to break down into particles which pass through # 10 mesh and no solid mass is left.

What is Disintegration Time of Capsules

30 Min.
What is Disintegration Time of uncoated tablet

Not more than 15 minutes.

What is Disintegration Time of Film-coated tabs?

Not more than 30 minutes.

What is Disintegration Time sugar-coated tablets?
Not more than 60 minutes.

What is Disintegration Time of Enteric-coated table?
Tablets which have Enteric-coating should not disintegrate for 2 hours in acidic media and then these tablets when placed in basic media should disintegrate within 1 hour.

What is the limit of friability

Not more than 1%

Defects of Coating
  • sticking
  • Colour variation
  • Orange peel effect
  • logo filling
  • chipping
  • Film cracking
Types of coating
  1. Film Coating
  2. Enteric Coating
  3. Sugar Coating

 What is HVAC?

Heating Ventilation and Air conditioning

Functions Of HVAC

  • Prevent cross-contamination
  • Maintain Temperature
  • Maintain Humidity
  • Create Differential Pressure
  • Maintain Air Changes  

 Types of capsules

  • Hard Gelatin Capsule
  • Soft Gelatin Capsule

Revolution of Friability

25 rpm per minute and run-time is 4 minutes.

Name of 3 Natural binders
  • Starch 
  • Cellulose
  • Gelatin
Name OF Synthetic Binder

PVP k 30 or kollidon, povidone.

Why do we manufacture granules?

Granules are prepared for tablet compression because of the following main reasons.

  • To enhance flow because powders flow is poor.
  • To prevent weight variation.
  • To reduce dusty environment because powders are dustier.
  • To prevent segregation.
  • To improve content uniformity.
  • To improve compaction.
  • Powders are elastic so tend to cap but granules are plastic so prevent tablet capping.
What is a rat hole?

Rathole is a powder flow defect in which powder adheres to the walls of compression machine hopper or blender walls and stops the flow against walls creating a hole in the middle. It results in weight variation and fragile tablets during compression.






25 comments:

  1. Add your interview questions in comment box to get answer in the post

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  2. Difference between GMP and cGMP

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    Replies
    1. GMP is a system to ensure products are consistently produced and controlled according to quality standards. The “c” in cGMP stands for current which indicates that the most recent standards, technology, and methods are being applied to operations.

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    2. GMP is a system to ensure products are consistently produced and controlled according to quality standards. The “c” in cGMP stands for current which indicates that the most recent standards, technology, and methods are being applied to operations.

      Delete
  3. How to calculate sample size for 100mg

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  4. Why we used 70% sorbitol solution why not 100?

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  5. Great work you are doing may Allah bless you JazakAllah

    ReplyDelete
  6. What is deviation and change control?.

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  7. What are the limitations of disintegration test and dissolution test.

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  8. Difference bet GMP and CGMP with examples ...

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    Replies
    1. https://www.pharmainform.com/2021/01/good-manufacturing-practicegmpdifferenc.html

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  9. It's v informative..keep it up

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  10. What is validation and types

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  11. Difference between validation and calibration

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    Replies
    1. Validation is for process nd calibration is for instrument.

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  12. validation is a whole process that assures the quality and durability and make the things up to date,
    while calibration is done for instrument to work properly.

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  13. Very informative Allah bless you sir

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