Standard Operating Procedure for Liquid Manufacturing Vessel.
The purpose of this SOP is to develop a standard procedure for operating the Liquid Manufacturing Vessel or syrup manufacturing vessel also known as SS manufacturing vessel.
This SOP applies to the Liquid Manufacturing Vessel used in the liquid manufacturing area of the production section.
3.1 Machine Operator is responsible for operating the Liquid Manufacturing Vessel.
3.2 Liquid Manufacturing Pharmacist is responsible for the implementation of this SOP.
3.3 The Head Of Production is responsible for ensuring the implementation of the current SOP.
3.4 Q.A. Officer monitors the compliance of this SOP.
4.1 Area Pharmacist shall ensure that the manufacturing vessel is properly cleaned from the inside including the propeller shaft ,blades, and silverson blades if attached.
4.2 Area Pharmacist shall ensure that the manufacturing vessel is properly cleaned from the outside including the vessel body & volume measuring glass rod.
4.3 Pharmacist shall ensure that the Liquid Manufacturing Vessel & area
is labeled with product-related labels
4.4 Take line clearance from the Quality Assurance officer.
4.5 After line clearance, ensure that the lower valve of the vessel is properly closed.
4.6 Open the upper lid of the vessel & transfer the required quantity of solvent into the vessel according to the BMR.
4.7 When the required volume is achieved, close the lid, insert the wire plug into the socket & press the ON button to start the propeller Mixer.
4.8 Open the upper lid again & add other ingredients according to the BMR & continue mixing till mentioned in BMR.
4.9 Use a Silverson mixer if required & adjust the volume at the end using a glass rod indicator attached on the outer side of the vessel & verify it by using a measuring rod.
4.10 Close the lid, turn off the propeller & silver son mixer & remove the wire plug.
4.11 Affix the ‘To be cleaned label’ and record the activity in the logbook of the liquid manufacturing vessel.
5.1 SOP: Standard Operating Procedure
5.2 BMR: Batch Manufacturing Record
5.3 QA: Quality Assurance
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