Calcium phosphate dibasic dihydrate is used as an excipient in pharmaceutical products and it is also used in dietary supplements as a source of calcium.It is also called DCP or dibasic calcium phosphate. Dibasic calcium phosphate is an insoluble and inorganic excipient.
Main Uses:
- It is used as a tablet diluent.
- It is also used as a capsule diluent.
Other Uses:
- It is used in toothpaste.
- Used as a food additive.
- It is used in poultry feed.
Note
- Calcium phosphate dibasic dihydrate is non-hygroscopic and is stable, but some time on specific conditions it may lose water of crystallization.
- DCP needs a swelling type of disintegrant when used as diluent.
Grades Of DCP
It has two gradesÂ
- Coarse grade
- Milled grade
Milled grades are used as a diluent in wet granulation and dry granulation
The coarse grade is used as a diluent in dry granulation because it has good flow properties.
Properties
- Dibasic calcium phosphate dihydrate or
- DCP has good compaction properties.
- DCP coarse grade deform by a brittle fracture.
- Dibasic calcium phosphate dihydrate or DCP is abrasive
Incompatible
Dibasic calcium phosphate dihydrate is incompatible with following,
- Aspirin
- Ampicillin antibiotic
- Aspartame a sweetener
- Erythromycin antibiotic
DCP has an alkaline surface so it should not be used with alkaline pH-sensitive drugs.
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Nice
thanks a lot for this information. it will help me