Calcium phosphate dibasic dihydrate is used as an excipient in pharmaceutical products and it is also used in dietary supplements as a source of calcium.It is also called DCP or dibasic calcium phosphate. Dibasic calcium phosphate is an insoluble and inorganic excipient.
Main Uses:
It is used as a tablet diluent.
It is also used as capsule diluent.
Other Uses:
It is used in toothpaste.
Used as a food additive.
It is used in poultry feed.
Calcium phosphate dibasic dihydrate is non-hygroscopic and is stable, but some time on specific conditions it may lose water of crystallization.
DCP needs a swelling type of disintegrant when used as diluent.
Grades Of DCP
It has two grades
- Coarse grade
- Milled grade
Milled grades are used as a diluent in wet granulation and dry granulation
The coarse grade is used as a diluent in dry granulation because it has good flow properties.
Properties
Dibasic calcium phosphate dihydrate or
DCP has good compaction properties.
DCP coarse grade deform by a brittle fracture.
Dibasic calcium phosphate dihydrate or DCP is abrasive
Incompatible
Dibasic calcium phosphate dihydrate is incompatible with following,
- Aspirin
- Ampicillin antibiotic
- Aspartame a sweetener
- Erythromycin antibiotic
DCP has an alkaline surface so it should not be used with alkaline pH-sensitive drugs.
Popular Posts:
- Classification of Excipients.
- Role of diluents in tablet granulation.
- Role of mannitol in pharmaceutical products.
- Uses of Starch and modified starch in tablet manufacturing.
- Different Grades of Microcrystalline Cellulose or Avicel .
Nice
thanks a lot for this information. it will help me