Mannitol in tablet formulation

Mannitol is an alcohol sugar present in many plants and animals. It is a hexahedral alcohol widely used as an excipient in tablet formulation in pharmaceutical industries.

Uses of Mannitol

Mannitol has many different uses as an excipient e.g

  • It is used as a Plasticizer.
  • It is used as Diluent 10-90%
  • It is a sweetening agent.
  • Tonicity agent.
  • Parenterally used as osmotic diuretics.

General properties of Mannitol

  • Mannitol gives laxative effect when it is used in large quantities.
  • it is non hygroscopic so mannitol is used in moisture-sensitive products.
  • It is also used in direct compression because of its spray-dried grade.
  • Processing time with mannitol is short because the drying time of mannitol is less. Mean when mannitol is used as a diluent in wet granulation its drying time is short, it dry in a short period.

In Chewable Tablets

Mannitol has widely used excipient in chewable tablets because it gives a sweet taste and mouth-feel so because of this effect it is used in chewable tablets.

Spray-dried Mannitol.

Mannitol is also available as spray-dried grade and spray dried grade is used in direct compression tablet formulation.

Tablets produced with spray-dried grade give more hardness than powdered mannitol.

Spray-dried mannitol flow rate is better than powder mannitol.

 Disintegration time of spray-dried mannitol is also short.

Powder mannitol has poor flow because it is in the form of fine powder. So when powder mannitol is used as a diluent in wet granulation of tablet manufacturing, it should be used intra-granular. When Mannitol is used in wet granulation it also reduces the drying time.

Also Read

  1. Use of starch and modified starch in pharmaceutical products.
  2. Types and classification of excipients.
  3. Role of Lactose in tablet granulation.
  4. Role of Croscarmellose Sodium.
  5. Role of Diabasic Calcium phosphate in tablet granulation.
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