Tuesday, November 3, 2020

Calcium Phosphate, dibasic dihydrate uses in tablets

 Calcium Phosphate, dibasic dihydrate

Calcium phosphate dibasic dihydrate is used as an excipient in pharmaceutical products and it is also used in dietary supplements as a source of calcium.

It is also called DCP or dibasic calcium phosphate. Dibasic calcium phosphate is an insoluble and inorganic excipient.

Main Uses:

It is used as a tablet diluent.

It is also used as capsule diluent.

Other Uses:

It is used in toothpaste.

Used as a food additive.

It is used in poultry feed.

Calcium phosphate dibasic dihydrate is non-hygroscopic and is stable, but some time on specific conditions it may lose water of crystallization.

DCP needs a swelling type of disintegrant when used as diluent.

Grades Of DCP

It has two grades 

  • Coarse grade

  • Milled grade

Milled grades are used as a diluent  in wet granulation and dry granulation

The coarse grade is used as a diluent in dry granulation because it has good flow properties.

Properties

Dibasic calcium phosphate dihydrate or

DCP has good compaction properties.

DCP coarse grade deform by a brittle fracture.

Dibasic calcium phosphate dihydrate or DCP is abrasive

Incompatible

Dibasic calcium phosphate dihydrate is incompatible with following,

  • Aspirin

  • Ampicillin antibiotic

  • Aspartame a sweetener

  • Erythromycin antibiotic

DCP has an alkaline surface so it should not be used with alkaline pH-sensitive drugs.

Popular Posts:


Classification of Excipients.


Role of diluents in tablet granulation.


Role of mannitol in pharmaceutical products.


Uses of Starch and modified starch in tablet manufacturing.


Different Grades of Microcrystalline Cellulose or Avicel .


Mechanism Of Action Of Aspirin







3 comments: