Kollidon CL | Crospovidone | Kollidon CL Used

Crospovidone is a cross-linked polyvinylpyrrolidone or Crosslinked PVP and is used as a super disintegrant in manufacturing of oral solid dosage forms in pharmaceutical industries.

Other Names

The other names used for crospovidone are as follow,

  • Kollidon CL
  • Kollidon CL M
  • PVPP
  • Crosspovidonum
  • Cross Linked Povidone
  • Polyplasdone XL
  • Insoluble Polyvinylpyrollidone

Mechanism Of Crospovidone

Crospovidone is insoluble in water and gives its disintegration effect by swelling without forming gel.

Uses Of Crospovidone

  • Crospovidone is used as a super disintegrant for manufacturing tablets and capsules by wet granulation,dry granulation and direct compression.
  • It is also used to improve the dissolution profile.
  • It is used to enhance the bioavailability of drugs.
  • Crospovidone is used as a solubility enhancer.
  • Kollidone CL M is used to stabilize the suspension.

Also Read

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Concentration Used

Crospovidone is used as a disintegrant in 2-5% concentration.

Grades Of Crospovidone

Crospovidone is available in following grades and these grades vary on the basis of particle size.

Swelling properties vary depending on the particle size.

  • Kollidon CL
  • Kollidon CL F
  • Kollidon CL-M
  • Kollidon CL-SF
  • Polyplasdone XL
  • Polyplasdone XL-10

Kollidon CL-F

  • It is available as fine powder.
  • It Improves disintegration.
  • Improve dissolution.
  • Good for small size tablets.
  • Improve surfface of tablets due to fine grade.

Kollidon CL-M

  • Kollidon CL-M is micronized grade of kollidon CL.
  • It has finest particle size.
  • It is insoluble in all solvents¬†
  • It is good for small sized tablets,granules and pellets.
  • It is used for stablizing the suspension both oral and topical suspensions.
  • It is used as solubilizer in transdermal patches.

Kollidon CL-SF

  • SF in Kollidon CL-SF represents ‘Super Fine’ means this grade has super fine particle size.
  • It is use in Orally Disintegrating tablets.
  • It gives creamy mouth feel in Orally disintegrating tablets.
  • It also gives good binding to Orally Disintegrating Tablets.
  • It enhances disintegration rate.

Also Read:

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Coating Of Core Tablets Containing Kollidon CL

  • Tablets that contain kollidon CL in their final blend should be coated carefully, if we are using aqueous coating.
  • Because in core tablets the Kollidon CL may show swelling properties when water comes in contact ,so before aqueous coating a seal coat in organic solvent should be applied,to coat the tablets with smooth surface and finishing.


Cross Linked Polyvinylpyrrolidone is hygroscopic so it should be stored in airtight containers.



  • Handbook Of Pharmaceutical Excipients.
  • Practical Observations.

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